Sleep is not optional. It is the physiological reset button. Without regular, high-quality sleep, the nervous system, metabolic regulation and cognitive performance all drift off balance.
Meta-analyses show that dietary supplements of amino acids—precursors of neurotransmitters—improve subjective sleep quality. And while magnesium and zinc show more variable data, their role in sleep physiology is plausible and increasingly studied.
At anatome, we’ve built our formula so that sleep support is not an afterthought—it is a system. The product in question, Sleep Supplement (Reset, Relax + Sleep), aligns directly with emerging research on nutrient and botanical sleep pathways.
Ingredient-by-Ingredient: The Science Behind the Formulation
Magnesium, Zinc & Vitamin B6
In our supplement: Magnesium 112.5 mg, Zinc 5 mg, Vitamin B6 1.4 mg.
Mechanistic rationale:
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Magnesium regulates hundreds of enzymatic reactions, including those affecting GABA signalling—the neurotransmitter system responsible for slowing neural activity and promoting calm.
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Zinc supports neurotransmitter balance and circadian rhythm.
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Vitamin B6 is an essential cofactor for converting tryptophan into serotonin and melatonin, the body’s natural sleep hormones.
Evidence:
A systematic review found amino acid supplementation improved subjective sleep quality, while magnesium and zinc demonstrated supportive but moderate effects. In older adults, magnesium supplementation was associated with improved sleep efficiency and reduced insomnia symptoms.
Interpretation:
These doses reflect a strategy of steady biological support rather than pharmacological force—reinforcing pathways rather than overriding them.
L-Glycine (300 mg)
Why it matters:
Glycine is both an inhibitory neurotransmitter and a thermoregulatory agent. It helps lower core body temperature—a natural trigger for sleep onset.
Human trials using 3 g of glycine before bed improved subjective sleep quality, reduced time to fall asleep, and enhanced next-day alertness without altering normal sleep stages.
Context:
Our formula uses a supportive 300 mg dose within a multi-ingredient system. Even at this level, glycine complements magnesium and tryptophan to calm the nervous system and promote the shift into rest mode.
L-Tryptophan (200 mg)
Mechanistic rationale:
Tryptophan is the precursor for serotonin and melatonin. Ensuring an adequate supply allows the body’s natural sleep cascade to function efficiently.
Clinical trials combining tryptophan and magnesium have shown improvements in sleep onset and morning alertness.
Interpretation:
By pairing tryptophan with Vitamin B6 and magnesium, the formula supports the neurochemical foundation of sleep—addressing the system rather than the symptom.
Botanicals: Chamomile, Hops, Bacopa monnieri
Why they matter:
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Chamomile extract provides apigenin, a bioflavonoid that binds to GABA receptors and promotes mild sedation.
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Hops contribute alpha acids that support relaxation and reduce sleep latency.
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Bacopa monnieri, an adaptogen, helps modulate stress hormones and has been shown to improve sleep quality and reduce fatigue in adults under stress.
So how do they work?
These botanicals target stress and hyper-arousal—the chief barriers to restorative sleep. Together they encourage parasympathetic dominance, allowing the body to transition naturally from alertness to restoration.
Why This Matters
Sleep loss is cumulative, it undermines emotional regulation, impairs memory consolidation, slows metabolic efficiency, and weakens immunity.
By addressing multiple dimensions—nutrient sufficiency, neurotransmitter balance, and stress moderation—this formula supports the body’s intrinsic sleep architecture.
